Medline references for Clinker/Age Pigment Theory of Aging

The theory assumes that accumulation of age pigments (examples are lipofuscin ans ceroid,- inert, fluorescent substances) causes several pathophysiological complications and is inversely correlated with aging.

Reviews:

Adv Gerontol Res 1971;3:147-70: Zeman W
The neuronal ceroid-lipofuscinoses--Batten-Vogt syndrome: a model for human aging?
Geriatrics 1976 May;31(5):128-37: Kent S
Solving the riddle of lipofuscin's origin may uncover clues to the aging process.
Adv Exp Med Biol 1980;129:71-98: Brizzee KR; Knox C
The aging process in the neuron.
Bull Schweiz Akad Med Wiss 1980 Apr;36(1-3):57-70: Lazorthes G
[Le vieillissement cellulaire et vasculaire de l'encephale.]
Ann Nutr Aliment 1980;34(2):317-32: Durand G; Desnoyers F
[Acides gras polyinsatures et vieillissement. Les lipofuscines : structure, origine, evolution.]
Rev Electroencephalogr Neurophysiol Clin 1981 Jul-Sep;10(3):215-27: Foncin JF
[Etude anatomo-pathologique et ultrastructurale de divers processus de vieillissement cerebral chez l'homme revue critique.]
In Vitro 1983 Feb;19(2):73-82: Kim SU
Neuronal aging in tissue and cell cultures: a review.
Clin Geriatr Med 1985 Feb;1(1):119-41: Klausner SC; Schwartz AB
The aging heart.
Clin Geriatr Med 1985 Feb;1(1):61-94: Vernadakis A
The aging brain.
Am J Med Genet Suppl 1988;5:183-91: Wisniewski HM; Wen GY
Lipopigment in the aging brain.
Adv Exp Med Biol 1989;266:17-26; discussion 27-9: Sohal RS; Brunk UT
Lipofuscin as an indicator of oxidative stress and aging.

Futher Information:

Accumulation of lipofuscin in

neurons

cardiac myocytes

cortex and hippocampus