Author(s): Baynes JW; Watkins NG; Fisher CI; Hull CJ; Patrick JS; Ahmed MU; Dunn JA; Thorpe SR

Address: Department of Chemistry, University of South Carolina, Columbia 29208.

Source: Prog Clin Biol Res 1989;304:43-67

Abstract: The Amadori Rearrangement Product is the first stable adduct formed during glycation (nonenzymatic glycosylation) of protein. This review deals with the structure of the Amadori adduct on protein, factors affecting the kinetics and specificity of glycation of protein, measurements of the extent of glycation of proteins in vivo, and the possible significance of glycation itself, versus post-glycation reactions, in the development of pathophysiology in diabetes

Major Indexes:

• Carbohydrates [metabolism]
• Maillard Reaction
• Proteins [metabolism]

• Aging [metabolism]
• Amines [metabolism]
• Diabetes Mellitus [metabolism]
• Glycoproteins [metabolism]
• Glycosylation
• Hydrogen-Ion Concentration
• Kinetics
• Molecular Conformation
• Oxidation-Reduction

• 0 (Amines)
• 0 (Glycoproteins)