Author(s): Monnier VM; Sell DR; Nagaraj RH; Miyata S
Address: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio.
Source: Gerontology 1991;37(1-3):152-65
Abstract: In order to prevent or escape the ongoing damage to proteins and DNA resulting from amino-carbonyl reactions, the organism has to have powerful defense mechanisms. If the Maillard reaction played a role in determining longevity among mammalian species, one would expect protective mechanisms to be more developed in long- versus short-lived species. This article summarizes current knowledge in this field, and discusses the concept of anti-Maillard mechanisms as a basis for the genetic regulation of molecular damage by reducing sugars in aging and diabetes
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