Medline references for Aging Reviews

Contents:

• Aging -- General Reviews
• Evolution of Aging Reviews
• Genetics and Aging
• DNA Damage/Repair and Aging
• DNA Methylation and Aging
• Mitochondrial DNA Damage and Aging
• Nutrition, Obesity and Aging
• Dietary Restriction and aging
• Immune System Senescence and Aging
• Hormones, Stress and Aging
• Cancer and Aging
• Telomeres, Cellular Senescence, Apoptosis and Aging
  • Telomeres
  • Apoptosis/Programmed Cell Death
• Protein Damage and Aging
• Exercise and Aging
• Sex specific Longevity Differences
• Accelerated Aging Diseases
  • Werners Syndrome
• Genes involved in Aging
• Organ/System Specific Aging
  • Brain Aging
  • Skin Aging
  • Liver Aging
  • Kidney Aging
  • Heart and Vasculature Aging
  • Reproductive System Aging
  • Miscellaneous System Age Changes
• Health Care
• Biomarkers, Animal Models and Aging Study Design

Aging -- General Reviews

• FASEB J 1994 Sep;8(12):925-8: Rose MR; Nusbaum TJ
  Prospects for postponing human aging.
  
• Ann N Y Acad Sci 1994 May 31;719 (1):474-82: Kloeden PE; Rossler R; Rossler OE
  Artificial life extension. The epigenetic approach.
  
• Z Gerontol 1994 May-Jun;27(3):166-71: Niedermuller H; Hofecker G
  [Is selection for extended life expectancy possible by regularity in aging?]
  
• Aging (Milano) 1994 Feb;6(1):5-23: Cooper EL
  Invertebrates can tell us something about senescence.
  
• Annu Rev Med 1993;44 (1):419-29: Martin GR; Danner DB; Holbrook NJ
  Aging--causes and defenses.
  
• Public Health Rev 1993-94;21(3-4):225-42: Davies AM
  Aging and epidemiology.
  
• Mech Ageing Dev 1993 Jun;69(1-2):65-77: Weale RA
  Have human biological functions evolved in support of a life-span?
  
• Genetica 1993;91(1-3):21-34: Bell G
  Pathogen evolution within host individuals as a primary cause of senescence.
  
• Z Rheumatol 1992 Nov-Dec;51(6):280-4: Platt D
  [Aging--from the molecule to the organism]
  
• Ugeskr Laeger 1992 Oct 12;154(42):2879-83: Sorensen TI; Borch-Johnsen K
  [Research of aging: epidemiological perspectives]
  
• Aging (Milano) 1993 Aug;5(4):277-89: Finch CE
  FRAR course on laboratory approaches to aging. Theories of aging.
  
• Aging (Milano) 1993 Aug;5(4):299-307: Johnson TE
  FRAR course on laboratory approaches to aging. Genetic influences on aging in mammals and invertebrates.
  
• Aging (Milano) 1993 Aug;5(4):259-67: Austad SN
  FRAR course on laboratory approaches to aging. The comparative perspective and choice of animal models in aging research.
  
• Aging (Milano) 1993 Aug;5(4):291-7: Treton JA
  FRAR course on laboratory approaches to aging. Cellular aging, in vitro and in vivo.
  
• J Gerontol 1993 Jul;48(4):B115-23: Promislow DE
  On size and survival: progress and pitfalls in the allometry of life span.
  
• Am J Clin Nutr 1992 Jun;55(6 Suppl):1267S-1270S: Butler RN
  Quality of life: can it be an endpoint? How can it be measured?
  
• Tanpakushitsu Kakusan Koso 1992 May;37(7):1347-52: Watanabe A
  [Molecular mechanism of plant senescence]
  
• Lab Anim Sci 1992 Apr;42(2):127-31: Maisin JR
  Life-shortening and causes of death in mice following exposure to ionizing radiation [published erratum appears in Lab Anim Sci 1992 Jun; 42(3):326]
  
• Clin Biochem 1992 Apr;25(2):61-75: Kirkland JL
  The biochemistry of mammalian senescence.
  
• Ann N Y Acad Sci 1991;621 (1):428-40: Franceschi C; Monti D; Cossarizza A; Fagnoni F; Passeri G; Sansoni P
  Aging, longevity, and cancer: studies in Down's syndrome and centenarians.
  
• Neurobiol Aging 1991 Nov-Dec;12(6):625-34: Finch CE
  New models for new perspectives in the biology of senescence.
  
• Med Anthropol 1991 Sep;13(3):215-29: Stini WA
  Body composition and longevity: is there a longevous morphotype?
  
• Int J Psychosom 1990;37(1-4):5-24: Morse DR; Rabinowitz H
  A unified theory of aging.
  
• Occup Med 1990 Oct-Dec;5(4):807-16: Thompson PG
  Aging in the 1990s and beyond.
  
• Exp Gerontol 1992;27(1):7-16: Finch CE
  Mechanisms in senescence: some thoughts in April 1990.
  
• ZFA 1988 Sep-Oct;43(5):243-9: Martin H; Rotzsch W
  [Possibilities and limits of the modifiability of aging from the viewpoint of experimental gerontology]
  
• Mech Ageing Dev 1987 Nov;41(1-2):1-28: Olson CB
  A review of why and how we age: a defense of multifactorial aging.
  
• Prog Clin Biol Res 1987;228 (1):25-80: Martin GM
  Interactions of aging and environmental agents: the gerontological perspective.
  
• Arch Intern Med 1987 Jan;147(1):166-9: Masoro EJ
  Biology of aging. Current state of knowledge.
  
• Dermatol Clin 1986 Jul;4(3):347-58: Balin AK; Allen RG
  Mechanisms of biologic aging.
  
• Acta Med Scand 1985;218(1):5-17: Svanborg A; Shibata H; Hatano S; Matsuzaki T
  Comparison of ecology, ageing and state of health in Japan and Sweden, the present and previous leaders in longevity.
  
• Clin Geriatr Med 1985 Feb;1(1):29-35: Walford RL
  The extension of maximum life span.
  
• N Engl J Med 1985 May 2;312(18):1159-68: Schneider EL; Reed JD Jr
  Life extension.
  
• Adv Vet Sci Comp Med 1984;28 (1):305-41: Bowden DM; Williams DD
  Aging.
  
• World Health Organ Tech Rep Ser 1984;706 (1):1-84:
  The uses of epidemiology in the study of the elderly. Report of a WHO Scientific Group on the Epidemiology of Aging.
  
• Pol Tyg Lek 1983 Jun 27;38(26):817-21: Zakowska-Wachelko B
  [Prolongation of life: theories and practical possibilities]
  
• Arch Gerontol Geriatr 1982 May;1(1):3-27: Economos AC
  Rate of aging, rate of dying and the mechanism of mortality.
  
• Minerva Med 1981 Sep 8;72(32):2111-22: Cavalieri U
  [Longevity: statement of a theme]
  
• Genet Psychol Monogr 1981 Aug;104(First Half):43-70: Nelson GK
  Senescence or where is the individual going? a developmental world view.
  
• Clin Endocrinol Metab 1981 Mar;10(1):3-22: Merry BJ; Phillips JG
  Basic gerontology.
  
• Plast Reconstr Surg 1981 Apr;67(4):536-50: Hayflick L
  The biology of human aging.
  
• Int J Biochem 1979;10(11):867-76: Hocman G
  Biochemistry of ageing.
  
• Gerontology 1979;25(3):136-44: Morrow J; Garner C
  An evaluation of some theories of the mechanism of aging.
  
• Mech Ageing Dev 1979 Feb;9(3-4):337-54: Cutler RG
  Evolution of human longevity: a critical overview.
  
• Birth Defects 1978;14(1):463-98: Cutler RG
  Alterations with age in the informational storage and flow systems of the mammalian cell.
  
• Geriatrics 1976 AUG;31(8):128-31: Kent S
  Longer life span hinges on control of aging as well as degenerative diseases.
  
• Q Rev Biol 1976 Mar;51(1):49-83: Finch CE
  The regulation of physiological changes during mammalian aging.
  
• Fed Proc 1975 Jan;34(1):9-13: Hayflick L
  Current theories of biological aging.
  

Evolution of Aging Reviews

• Genetica 1993;91(1-3):11-9: Charlesworth B
  Evolutionary mechanisms of senescence.
  
• Genetica 1993;91(1-3):89-98: Partridge L; Barton NH
  Evolution of aging: testing the theory using Drosophila.
  
• Genetica 1993;91(1-3):79-88: Reznick D
  New model systems for studying the evolutionary biology of aging: crustacea.
  
• Genetica 1993;91(1-3):279-86: Albin RL
  Antagonistic pleiotropy, mutation accumulation, and human genetic disease.
  
• Genetica 1993;91(1-3):265-77: Martin GM
  Abiotrophic gene action in Homo sapiens: potential mechanisms and significance for the pathobiology of aging.
  
• Genetica 1993;91(1-3):225-38: Crew MD
  Genes of the major histocompatibility complex and the evolutionary genetics of lifespan.
  
• Horm Res 1993;39 (1):Suppl 1 p5-8: Suzuki K
  Origin of senescence: a review.
  
• Am J Clin Nutr 1992 Jun;55(6 Suppl):1191S-1195S: Kirkwood TB
  Comparative life spans of species: why do species have the life spans they do?
  
• Philos Trans R Soc Lond [Biol] 1991 Apr 29;332(1262):15-24: Kirkwood TB; Rose MR
  Evolution of senescence: late survival sacrificed for reproduction.
  
• Genome 1989;31(1):398-405: Kirkland JL
  Evolution and ageing.
  
• Perspect Biol Med 1982 Spring;25(3):339-53: Sacher GA
  Evolutionary theory in gerontology.
  
• Fed Proc 1979 May;38(6):1962-7: Martin GM
  Genetic and evolutionary aspects of aging.
  

Genetics and Aging

• Genetica 1993;91(1-3):151-65: Dixon LK
  Use of recombinant inbred strains to map genes of aging.
  
• Hum Genet 1993 Jul;91(6):519-26: Schachter F; Cohen D; Kirkwood T
  Prospects for the genetics of human longevity.
  
• Genetica 1993;91(1-3):35-51: Jazwinski SM
  The genetics of aging in the yeast Saccharomyces cerevisiae.
  
• Genetica 1993;91(1-3):65-77: Johnson TE; Tedesco PM; Lithgow GJ
  Comparing mutants, selective breeding, and transgenics in the dissection of aging processes of Caenorhabditis elegans.
  
• Exp Gerontol 1993 Mar-Apr;28(2):109-18: Kloeden PE; Rossler R; Rossler OE
  Timekeeping in genetically programmed aging.
  
• EXS 1992;62 (1):31-46: Cutler RG
  Genetic stability and oxidative stress: common mechanisms in aging and cancer.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):17-25: Hanawalt PC; Gee P; Ho L; Hsu RK; Kane CJ
  Genomic heterogeneity of DNA repair. Role in aging?
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):4-16: Franceschi C; Monti D; Scarfi MR; Zeni O; Temperani P; Emilia G; Sansoni P; Lioi MB; Troiano L; Agnesini C; et al
  Genomic instability and aging. Studies in centenarians (successful aging) and in patients with Down's syndrome (accelerated aging).
  
• J Am Geriatr Soc 1992 Sep;40(9):936-45: Johnson TE; Lithgow GJ
  The search for the genetic basis of aging: the identification of gerontogenes in the nematode Caenorhabditis elegans.
  
• Mutat Res 1992 Aug;277(2):139-62: Smith KC
  Spontaneous mutagenesis: experimental, genetic and other factors.
  
• Mutat Res 1991 Mar-Nov;256(2-6):323-8: Kirkwood TB
  Genetic basis of limited cell proliferation.
  
• Annu Rev Gerontol Geriatr 1990;10 (1):97-116: Goldstein S
  Molecular genetic approaches to mechanisms of senescence.
  
• Mol Microbiol 1990 Mar;4(3):337-43: Jazwinski SM
  Aging and senescence of the budding yeast Saccharomyces cerevisiae.
  
• Med Hypotheses 1988 Oct;27(2):133-40: Bounous G; Kongshavn PA; Taveroff A; Gold P
  Evolutionary traits in human milk proteins.
  
• Science 1987 Oct 9;238(4824):163-70: Holliday R
  The inheritance of epigenetic defects.
  
• Exp Gerontol 1986;21(4-5):283-319: Strehler BL
  Genetic instability as the primary cause of human aging.
  
• Int Rev Cytol 1985;95 (1):61-102: Mayer PJ; Baker GT 3d
  Genetic aspects of Drosophila as a model system of eukaryotic aging.
  
• Arch Gerontol Geriatr 1984 Oct;3(3):207-22: Markides KS; Machalek R
  Selective survival, aging and society.
  
• Tsitol Genet 1983 Mar-Apr;17(2):65-73: Voitenko VP
  [Heredity, aging and human longevity]
  
• Yale J Biol Med 1982 Sep-Dec;55(5-6):487-513: Scriver CR
  Window panes of eternity. Health, disease, and inherited risk.
  
• Adv Pathobiol 1980;7 (1):5-20: Martin GM
  Genotropic theories of aging: an overview.
  
• Adv Exp Med Biol 1980;129 (1):123-37: Hart RW; Modak SP
  Aging and changes in genetic information.
  
• Mech Ageing Dev 1979 Feb;9(3-4):325-36: Brown WT
  Human mutations affecting aging--a review.
  
• Geriatrics 1978 Sep;33(9):109-12, 116: Kent S
  Body temperature and life span.
  

DNA Damage/Repair and aging

• Mutat Res 1994 Jun 1;307(2):451-9: Gossen JA; de Leeuw WJ; Vijg J
  LacZ transgenic mouse models: their application in genetic toxicology.
  
• Cancer Res 1994 Apr 1;54(7 Suppl):1899s-1901s: Satoh MS; Lindahl T
  Enzymatic repair of oxidative DNA damage.
  
• J Photochem Photobiol B 1993 Jul;19(2):87-96: Boiteux S
  Properties and biological functions of the NTH and FPG proteins of Escherichia coli: two DNA glycosylases that repair oxidative damage in DNA.
  
• Mol Neurobiol 1993 Spring;7(1):23-48: Rao KS
  Genomic damage and its repair in young and aging brain.
  
• Mutat Res 1992 Sep;275(3-6):317-29: Rao KS; Loeb LA
  DNA damage and repair in brain: relationship to aging.
  
• EXS 1992;62 (1):20-30: Simic MG
  The rate of DNA damage and aging.
  
• J Gerontol 1992 Nov;47(6):B177-84: Boerrigter ME; Wei JY; Vijg J
  DNA repair and Alzheimer's disease.
  
• Z Gerontol 1991 Nov-Dec;24(6):323-32: Schroder HC; Zahn RK; Muller WE
  [Environmentally-induced causes of aging-dependent DNA modifications and possible consequences: current methods for the assessment of genotoxic potential of mixed pollution]
  
• Mutat Res 1991 Mar-Nov;256(2-6):81-104: Macieira-Coelho A
  Chromatin reorganization during senescence of proliferating cells.
  
• Int J Neurosci 1990 Feb;50(3-4):169-74: Mazzarello P; Focher F; Verri A; Spadari S
  Misincorporation of uracil into DNA as possible contributor to neuronal aging and abiotrophy.
  
• Mutat Res 1990 Sep-Nov;237(5-6):189-210: Mullaart E; Lohman PH; Berends F; Vijg J
  DNA damage metabolism and aging.
  
• Mutat Res 1990 May;238(3):245-53: Randerath K; Li DH; Randerath E
  Age-related DNA modifications (I-compounds): modulation by physiological and pathological processes.
  
• Bioessays 1990 Feb;12(2):74-9: Mitchell DL; Hartman PS
  The regulation of DNA repair during development.
  
• J Gerontol 1989 Nov;44(6):45-54: Warner HR; Price AR
  Involvement of DNA repair in cancer and aging.
  
• Mech Ageing Dev 1989 Sep;49(3):259-70: Newton RK; Ducore JM; Sohal RS
  Relationship between life expectancy and endogenous DNA single-strand breakage, strand break induction and DNA repair capacity in the adult housefly, Musca domestica.
  
• Int Rev Cytol 1989;116 (1):47-88: Rattan SI
  DNA damage and repair during cellular aging.
  
• Mutat Res 1989 Jan;219(1):1-7: Kirkwood TB
  DNA, mutations and aging.
  
• Mutat Res 1988 Sep; (1):7-13: Kirkwood TB
  DNA, mutations and aging.
  
• Mech Ageing Dev 1987 Nov;41(1-2):47-63: Vijg J; Uitterlinden AG
  A search for DNA alterations in the aging mammalian genome: an experimental strategy.
  
• Ontogenez 1987 May-Jun;18(3):229-38: S'iakste NI
  [The role of DNA breaks in the regulation of cell proliferation, differentiation and aging]
  
• Biol Rev Camb Philos Soc 1987 Feb;62(1):25-44: Sen S; Talukder G; Sharma A
  Age-related alterations in human chromosome composition and DNA content in vitro during senescence.
  
• Tsitol Genet 1986 Jul-Aug;20(4):304-13: Kuznetsova SM; Zaritskaia MIu
  [Chromosomes. Aging. Longevity]
  
• IARC Sci Publ 1985;(58):203-13: Lehmann AR
  Ageing, DNA repair of radiation damage and carcinogenesis: fact and fiction.
  
• Mech Ageing Dev 1984 Dec;28(2-3):139-54: Medvedev ZA
  Age changes of chromatin. A review.
  
• Mech Ageing Dev 1984 Aug;26(2-3):149-64: Scalabrino G; Ferioli ME
  Polyamines in mammalian ageing: an oncological problem, too? A review.
  
• Q Rev Biol 1981 Sep;56(3):279-303: Gensler HL; Bernstein H
  DNA damage as the primary cause of aging.
  
• Mech Ageing Dev 1979 Feb;9(3-4):203-23: Hart RW; D'Ambrosio SM; Ng KJ; Modak SP
  Longevity, stability and DNA repair.
  
• Gerontology 1976;22(1-2):28-55: Little JB
  Relationship between DNA repair capacity and cellular aging.
  
• : Day RS 3d
  Inducible error-prone repair and cellular senescence. pp. 217-23.
  
• J Environ Pathol Toxicol 1978 Sep-Oct;2(1):79-114: Brash DE; Hart RW
  DNA damage and repair in vivo.
  
• Usp Sovrem Biol 1979 Jan-Feb;87(1):34-48: Vilenchik MM
  [Role of DNA repair disorders in chromosome instability, decreased longevity and neoplastic cell transformation in hereditary human diseases]
  

DNA Methylation and Aging

• Mol Biol (Mosk) 1994 Jan-Feb;28(1):21-51: Mazin AL
  [Enzymatic DNA methylation as an aging mechanism]
  
• Growth Dev Aging 1993 Winter;57(4):261-73: Cooney CA
  Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging.
  
• Med Hypotheses 1993 Jul;41(1):83-92: Tollefsbol TO; Andrews LG
  Mechanisms for methylation-mediated gene silencing and aging.
  
• Mutat Res 1991 Mar-Nov;256(2-6):105-13: Hornsby PJ; Yang LQ; Raju SG; Cheng CY
  Changes in gene expression and DNA methylation in adrenocortical cells senescing in culture.
  

Mitochondrial DNA Damage and Aging

• J Bioenerg Biomembr 1994 Jun;26(3):241-50: Wallace DC
  Mitochondrial DNA mutations in diseases of energy metabolism.
  
• J Clin Epidemiol 1993 Feb;46(2):199-201: Sont JK; Vandenbroucke JP
  Life expectancy and mitochondrial DNA. Do we inherit longevity from our mother's mitochondria?
  
• Mutat Res 1992 Sep;275(3-6):249-55: Richter C
  Reactive oxygen and DNA damage in mitochondria.
  
• Mutat Res 1992 Sep;275(3-6):169-80: Corral-Debrinski M; Shoffner JM; Lott MT; Wallace DC
  Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease.
  
• Mutat Res 1992 Sep;275(3-6):209-16: Miquel J
  An update on the mitochondrial-DNA mutation hypothesis of cell aging.
  
• Mutat Res 1992 Sep;275(3-6):157-67: Arnheim N; Cortopassi G
  Deleterious mitochondrial DNA mutations accumulate in aging human tissues.
  
• Mutat Res 1992 Sep;275(3-6):227-35: Shay JW; Werbin H
  New evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging.
  
• Mutat Res 1992 Sep;275(3-6):195-208: Linnane AW; Zhang C; Baumer A; Nagley P
  Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention.
  
• Mutat Res 1992 Sep;275(3-6):295-304: Sohal RS; Brunk UT
  Mitochondrial production of pro-oxidants and cellular senescence.
  
• Brain Pathol 1992 Apr;2(2):149-58: Muller-Hocker J
  Mitochondria and ageing.
  
• EXS 1992;62 (1):47-57: Miquel J; de Juan E; Sevila I
  Oxygen-induced mitochondrial damage and aging.
  
• Aging (Milano) 1992 Dec;4(4):273-86: Osiewacz HD; Hermanns J
  The role of mitochondrial DNA rearrangements in aging and human diseases.
  
• Free Radic Biol Med 1990;8(6):523-39: Bandy B; Davison AJ
  Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?
  
• Gerontology 1982;28(1):44-53: Fleming JE; Miquel J; Cottrell SF; Yengoyan LS; Economos AC
  Is cell aging caused by respiration-dependent injury to the mitochondrial genome?
  

Nutrition, Obesity and Aging

• Proc Soc Exp Biol Med 1994 Feb;205(2):97-105: Yu BP
  How diet influences the aging process of the rat.
  
• J Am Diet Assoc 1994 Jun;94(6):641-4: Abernathy RP; Black DR
  Is adipose tissue oversold as a health risk?
  
• Genetica 1993;91(1-3):239-53: Mobbs CV
  Genetic influences on glucose neurotoxicity, aging, and diabetes: a possible role for glucose hysteresis.
  
• South Med J 1992 Aug;85(8):2S22-30: Ettinger B
  Role of calcium in preserving the skeletal health of aging women.
  
• Annu Rev Nutr 1984;4 (1):471-91: Avioli LV
  Calcium and osteoporosis.
  
• Fed Proc 1980 Dec;39(14):3178-82: Masoro EJ; Yu BP; Bertrand HA; Lynd FT
  Nutritional probe of the aging process.
  
• Am J Clin Nutr 1979 Dec;32(12 Suppl):2723-33: Van Itallie TB
  Obesity: adverse effects on health and longevity.
  
• Fed Proc 1979 May;38(6):1994-2000: Young VR
  Diet as a modulator of aging and longevity.
  
• Fed Proc 1979 May;38(6):2017-22: Lytle LD; Altar A
  Diet, central nervous system, and aging.
  
• Adv Exp Med Biol 1978;97 (1):85-110: Young VR
  Nutrition and aging.
  
• Nutr Rev 1977 Feb;35(2):49-50:
  Dietary preference, growth, aging and lifespan.
  
• Pediatr Res 1977 Oct;11(10 Pt 2):1081-3: McCance RA; Widdowson EM
  Fat.
  
• MISSING SOURCE: Stunkard AJ
  Nutrition, aging and obesity. pp. 253-84.
  
• MISSING SOURCE: Jakubczak LF
  Behavioral aspects of nutrition and longevity in animals. pp. 103-22.
  
• MISSING SOURCE: Gerritsen GC
  The role of nutrition to diabetes in relation to age. pp. 229-52.
  
• Mech Ageing Dev 1979 Feb;9(3-4):225-36: Robinson AB
  Molecular clocks, molecular profiles, and optimum diets: three approaches to the problem of aging.
  

Dietary Restriction and Aging

• Ann N Y Acad Sci 1994 May 31;719 (1):171-94: Leakey JE; Chen S; Manjgaladze M; Turturro A; Duffy PH; Pipkin JL; Hart RW
  Role of glucocorticoids and "caloric stress" in modulating the effects of caloric restriction in rodents.
  
• Mutat Res 1993 Dec;295(4-6):237-45: Haley-Zitlin V; Richardson A
  Effect of dietary restriction on DNA repair and DNA damage.
  
• J Am Geriatr Soc 1993 Sep;41(9):994-9: Masoro EJ
  Dietary restriction and aging.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):575-81: Weindruch R
  Effect of caloric restriction on age-associated cancers.
  
• Growth Dev Aging 1993 Winter;57(4):233-49: Graves JL
  The costs of reproduction and dietary restriction: parallels between insects and mammals.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):583-92: Turturro A; Hart R
  Dietary alteration in the rates of cancer and aging.
  
• Am J Clin Nutr 1992 Jun;55(6 Suppl):1250S-1252S: Masoro EJ
  Retardation of aging processes by food restriction: an experimental tool.
  
• Lab Anim Sci 1992 Apr;42(2):132-7: Masoro EJ
  Aging and proliferative homeostasis: modulation by food restriction in rodents.
  
• Aging (Milano) 1991 Dec;3(4):384-6: Masoro EJ
  How does dietary restriction alter aging and survival in rodents?
  
• Ann N Y Acad Sci 1991;621 (1):353-62: Pieri C
  Food restriction slows down age-related changes in cell membrane parameters.
  
• Ann N Y Acad Sci 1991;621 (1):337-52: Masoro EJ; Shimokawa I; Yu BP
  Retardation of the aging processes in rats by food restriction.
  
• Annu Rev Gerontol Geriatr 1990;10 (1):183-97: Masoro EJ; McCarter RJ
  Dietary restriction as a probe of mechanisms of senescence.
  
• Basic Life Sci 1990;53 (1):351-61: Hart RW; Turturro A; Pegram RA; Chou MW
  Effects of caloric restriction on the maintenance of genetic fidelity.
  
• Proc Soc Exp Biol Med 1990 Jan;193(1):16-22: Fernandes G; Venkatraman J; Khare A; Horbach GJ; Friedrichs W
  Modulation of gene expression in autoimmune disease and aging by food restriction and dietary lipids.
  
• Geriatrics 1990 Apr;45(4):81-3, 86-7: Walford RL
  The clinical promise of diet restriction.
  
• J Gerontol 1989 Nov;44(6):67-71: Weindruch R
  Dietary restriction, tumors, and aging in rodents.
  
• Int J Radiat Biol 1988 Sep;54(3):309-65: Rubin JS
  The molecular genetics of the incision step in the DNA excision repair process.
  
• J Nutr 1987 Oct;117(10):1650-4: Walford RL; Harris SB; Weindruch R
  Dietary restriction and aging: historical phases, mechanisms and current directions.
  
• J Am Geriatr Soc 1985 Feb;33(2):125-32: Weindruch R
  Aging in rodents fed restricted diets.
  

Oxidants, Free Radicals, Antioxidants and Aging

• Ther Umsch 1994 Jul;51(7):467-74: Ballmer PE; Reinhart WH; Gey KF
  [Antioxidant vitamins and disease--risk of a suboptimal supply]
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):85-96: Ames BN; Shigenaga MK
  Oxidants are a major contributor to aging.
  
• Med Hypotheses 1993 Nov;41(5):473-82: Greenstock CL
  Radiation and aging: free radical damage, biological response and possible antioxidant intervention.
  
• Basic Life Sci 1993;61 (1):419-36: Shigenaga MK; Ames BN
  Oxidants and mitogenesis as causes of mutation and cancer: the influence of diet.
  
• Proc Natl Acad Sci U S A 1993 Sep 1;90(17):7915-22: Ames BN; Shigenaga MK; Hagen TM
  Oxidants, antioxidants, and the degenerative diseases of aging.
  
• Toxicol Ind Health 1993 Jan-Apr;9(1-2):151-61: Warner HR
  Overview: mechanisms of antioxidant action on life span.
  
• J Dairy Sci 1993 Sep;76(9):2789-94: Bendich A
  Physiological role of antioxidants in the immune system.
  
• Mutat Res 1994 Feb;317(1):25-42: Clayson DB; Mehta R; Iverson F
  International Commission for Protection Against Environmental Mutagens and Carcinogens. Oxidative DNA damage--the effects of certain genotoxic and operationally non-genotoxic carcinogens.
  
• Magnes Res 1993 Dec;6(4):369-78: Rayssiguier Y; Durlach J; Gueux E; Rock E; Mazur A
  Magnesium and ageing. I. Experimental data: importance of oxidative damage.
  
• J Toxicol Environ Health 1993 Oct-Nov;40(2-3):391-404: Loft S; Fischer-Nielsen A; Jeding IB; Vistisen K; Poulsen HE
  8-Hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage.
  
• Br Med Bull 1993 Jul;49(3):653-67: Nohl H
  Involvement of free radicals in ageing: a consequence or cause of senescence.
  
• Z Gerontol 1993 Jul-Aug;26(4):215-20: von Zglinicki T; Brunk UT
  Intracellular interactions under oxidative stress and aging: a hypothesis.
  
• Clin Lab Med 1993 Jun;13(2):463-80: Bankson DD; Kestin M; Rifai N
  Role of free radicals in cancer and atherosclerosis.
  
• J Pineal Res 1993 May;14(4):151-68: Poeggeler B; Reiter RJ; Tan DX; Chen LD; Manchester LC
  Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis.
  
• Med Lab Sci 1992 Dec;49(4):299-312: Bunker VW
  Free radicals, antioxidants and ageing.
  
• EXS 1992;62 (1):308-22: Henrotin Y; Deby-Dupont G; Deby C; Franchimont P; Emerit I
  Active oxygen species, articular inflammation and cartilage damage.
  
• Ann N Y Acad Sci 1992 Dec 26;673 (1):126-41: Harman D
  Role of free radicals in aging and disease.
  
• Mutat Res 1992 Sep;275(3-6):257-66: Harman D
  Free radical theory of aging.
  
• Ann N Y Acad Sci 1992 Sep 30;669 (1):7-20: Sies H; Stahl W; Sundquist AR
  Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):74-84: Sohal RS; Orr WC
  Relationship between antioxidants, prooxidants, and the aging process.
  
• Mutat Res 1992 Sep;275(3-6):305-15: Holmes GE; Bernstein C; Bernstein H
  Oxidative and other DNA damages as the basis of aging: a review.
  
• Integr Physiol Behav Sci 1992 Jul-Sep;27(3):216-27: Joseph JA
  The putative role of free radicals in the loss of neuronal functioning in senescence.
  
• FASEB J 1992 Jun;6(9):2675-83: Harris ED
  Regulation of antioxidant enzymes.
  
• Ann Neurol 1992;32 (1):Suppl pS22-7: Floyd RA; Carney JM
  Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress.
  
• Mutat Res 1992 Sep;275(3-6):267-79: Fleming JE; Reveillaud I; Niedzwiecki A
  Role of oxidative stress in Drosophila aging.
  
• Annu Rev Gerontol Geriatr 1990;10 (1):198-213: Allen RG
  Role of free radicals in senescence.
  
• Ann N Y Acad Sci 1991;621 (1):1-28: Cutler RG
  Human longevity and aging: possible role of reactive oxygen species.
  
• Mutat Res 1991 Mar-Nov;256(2-6):177-89: Poot M
  Oxidants and antioxidants in proliferative senescence.
  
• Prostaglandins Leukot Essent Fatty Acids 1991 Jun;43(2):63-70: Franson RC; Rosenthal MD; Regelson W
  Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity.
  
• Int J Neurosci 1991 Mar;57(1-2):1-17: Jesberger JA; Richardson JS
  Oxygen free radicals and brain dysfunction.
  
• Gerontology 1991;37(1-3):166-80: Pacifici RE; Davies KJ
  Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited.
  
• Am J Clin Nutr 1991 Jan;53(1 Suppl):373S-379S: Cutler RG
  Antioxidants and aging.
  
• Exp Gerontol 1990;25(6):499-522: Sohal RS; Allen RG
  Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis [see comments]
  
• Exp Eye Res 1990 Jun;50(6):677-82: Garland D
  Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis.
  
• Mutat Res 1989 Sep;214(1):41-6: Ames BN
  Endogenous DNA damage as related to cancer and aging.
  
• Free Radic Res Commun 1989;7(3-6):121-8: Ames BN
  Endogenous oxidative DNA damage, aging, and cancer.
  
• Basic Life Sci 1985;35 (1):15-73: Cutler RG
  Antioxidants and longevity of mammalian species.
  
• Annu Rev Physiol 1986;48 (1):657-67: Pryor WA
  Oxy-radicals and related species: their formation, lifetimes, and reactions.
  
• Vopr Med Khim 1982 Jul-Aug;28(4):8-25: Gusev VA; Panchenko LF
  [Superoxide radical and superoxide dismutase in the free-radical theory of aging (a review)]
  
• Arch Gerontol Geriatr 1982 Dec;1(4):299-310: Weber HU; Fleming JF; Miquel J
  Thiazolidine-4-carboxylic acid, a physiologic sulfhydryl antioxidant with potential value in geriatric medicine.
  
• J Gerontol 1980 Jan;35(1):45-56: Leibovitz BE; Siegel BV
  Aspects of free radical reactions in biological systems: aging.
  

Immune System Senescence and Aging

• Ann Neurol 1994;35 (1):Suppl pS35-7: Weksler ME
  Immune senescence.
  
• Compr Ther 1994;20(5):300-5: Heuser MD; Colvin PL Jr
  The "peripneumonia" period in the older adult.
  
• Exp Clin Immunogenet 1992;9(4):182-7: Weksler ME; Schwab R
  The immunogenetics of immune senescence.
  
• Eur J Clin Pharmacol 1993;45 (1):Suppl 1 pS21-3; discussion S43-4: Weksler ME
  Immune senescence and adrenal steroids: immune dysregulation and the action of dehydroepiandrosterone (DHEA) in old animals.
  
• Dig Dis 1993;11(3):157-72: Kawanishi H
  Recent progress in senescence-associated gut mucosal immunity.
  
• J Gerontol 1993 Jan;48(1):B3-7: Ershler WB
  The influence of an aging immune system on cancer incidence and progression [see comments]
  
• Adv Exp Med Biol 1993;330 (1):13-26: Mandelblatt J
  Squamous cell cancer of the cervix, immune senescence and HPV: is cervical cancer an age-related neoplasm?
  
• Ann N Y Acad Sci 1992 Dec 26;673 (1):231-9: Hadden JW; Malec PH; Coto J; Hadden EM
  Thymic involution in aging. Prospects for correction.
  
• Int J Immunopharmacol 1992 Apr;14(3):345-52: Hadden JW
  Thymic endocrinology.
  
• Cancer Invest 1992;10(6):525-31: Ben-Yehuda A; Weksler ME
  Immune senescence: mechanisms and clinical implications.
  
• Am J Clin Nutr 1992 Jun;55(6 Suppl):1215S-1221S: Smith JR; Ning Y; Pereira-Smith OM
  Why are transformed cells immortal? Is the process reversible?
  
• Environ Health Perspect 1991 Jun;93 (1):59-62: Sager R
  Senescence as a mode of tumor suppression.
  
• Mech Ageing Dev 1990 Apr 30;53(3):267-75: Ferluga J
  Potential role of anti-oncogenes in aging.
  
• Med Hypotheses 1990 Jun;32(2):145-9: Stone OJ
  Autoantibodies in aging: an attempt to correct a weakening debridement mechanism.
  
• Exp Gerontol 1986;21(3):129-48: Tollefsbol TO; Cohen HJ
  Expression of intracellular biochemical defects of lymphocytes in aging: proposal of a general aging mechanism which is not cell-specific.
  
• Am J Med 1986 Jul 28;81(1A):53-8: Garibaldi RA; Nurse BA
  Infections in the elderly.
  
• Med Clin North Am 1985 May;69(3):465-74: Busby J; Caranasos GJ
  Immune function, autoimmunity, and selective immunoprophylaxis in the aged.
  
• Gerontology 1985;31(4):263-77: Zatz MM; Goldstein AL
  Thymosins, lymphokines, and the immunology of aging.
  
• Monogr Dev Biol 1984;17 (1):110-21: Weksler ME; Siskind GW
  The cellular basis of immune senescence.
  
• Pharmacol Rev 1984 Jun;36(2 Suppl):123S-129S: Fernandes G
  Nutritional factors: modulating effects on immune function and aging.
  
• Gerontology 1984;30(3):188-95: Oyeyinka GO
  Age and sex differences in immunocompetence.
  
• Age Ageing 1984 Sep;13(5):291-4: Kafetz K
  The main histocompatibility complex and ageing in mice and men.
  
• Med Clin North Am 1983 Mar;67(2):263-72: Weksler ME
  Senescence of the immune system.
  
• Recenti Prog Med 1981 Aug;71(2):185-201: Montella F; Voci MC; Aiuti F
  [The immunobiological problem of senescence]
  
• Ontogenez 1980;11(5):511-7: Anokhin Iu N; Iarilin AA; Norets TA
  [Age-related changes in splenic lymphocyte migration in mice]
  
• Adv Exp Med Biol 1980;129 (1):213-31: Makinodan T
  Role of the immune system in aging.
  
• Ter Arkh 1979;51(6):101-6: Mazharov MK
  [Immunity and aging]
  
• Nippon Naika Gakkai Zasshi 1979 Mar 10;68(3):263-75: Kishimoto S
  [Immunologic aspects of senescence (author's transl)]
  
• Birth Defects 1978;14(1):197-212: Makinodan T
  Mechanism, prevention, and restoration of immunologic aging.
  
• Mech Ageing Dev 1977 Mar-Apr;6(2):115-29: Segre D; Segre M
  Age-related changes in B and T lymphocytes and decline of humoral immune responsiveness in aged mice.
  

Hormones, Stress and Aging

• Ann N Y Acad Sci 1994 May 31;719 (1):483-93: Anisimov VN; Khavinson VKh; Morozov VG
  Twenty years of study on effects of pineal peptide preparation: epithalamin in experimental gerontology and oncology.
  
• Ann N Y Acad Sci 1994 May 31;719 (1):456-60: Lesnikov VA; Pierpaoli W
  Pineal cross-transplantation (old-to-young and vice versa) as evidence for an endogenous "aging clock"
  
• J Gerontol 1993 Sep;48 (1):ec No p51-5: Joseph JA; Roth GS
  Hormonal regulation of motor behavior in senescence.
  
• Horm Res 1992;37 (1):Suppl 3 p1-10: McEwen BS
  Steroid hormones: effect on brain development and function.
  
• Aging (Milano) 1992 Sep;4(3):197-210: Stein-Behrens BA; Sapolsky RM
  Stress, glucocorticoids, and aging.
  
• J Steroid Biochem Mol Biol 1990 Nov 20;37(3):387-94: de Kloet ER; Reul JM; Sutanto W
  Corticosteroids and the brain.
  
• Mech Ageing Dev 1988 Nov 14;45(2):93-110: Thakur MK
  Molecular mechanism of steroid hormone action during aging. A review.
  
• Rev Clin Basic Pharm 1987 Apr-Jun;6(2):105-18: Scarpace PJ; Armbrecht HJ
  Adenylate cyclase in senescence: catecholamine and parathyroid hormone pathways.
  
• Sem Hop 1983 Jan 13;59(2):77-85: Vague J
  [Hormones and aging. 2]
  
• Biol Neonate 1980;37(3-4):113-37: Lamers WH; Mooren PG
  Role of glucocorticosteroid hormones on the levels of rat liver carbamoylphosphate synthase (ammonia) and arginase activity during ontogenesis.
  
• Life Sci 1982 Aug 16;31(7):615-23: Bolla RI
  Current concepts: II. Hormonal regulation of molecular events during aging.
  

Cancer and Aging

• Cancer 1994 Oct 1;74(7 Suppl):2092-100: Cohen HJ
  Biology of aging as related to cancer.
  
• Ann N Y Acad Sci 1994 May 31;719 (1):494-501: Anisimov VN
  The sole DNA damage induced by bromodeoxyuridine is sufficient for initiation of both aging and carcinogenesis in vivo.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):567-74: Hart RW; Turturro A
  Overview of cancer and aging: a mechanistic perspective.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):533-49: Randerath K; Li D; Nath R; Randerath E
  Exogenous and endogenous DNA modifications as monitored by 32P-postlabeling: relationships to cancer and aging.
  
• Science 1983 Sep 23;221(4617):1256-64: Ames BN
  Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):551-8: Ershler WB
  Explanations for reduced tumor proliferative capacity with age.
  
• Exp Gerontol 1992 Jul-Aug;27(4):397-401: Campisi J
  Oncogenes, protooncogenes, and tumor suppressor genes: a hitchhiker's guide to senescence?
  
• Breast Cancer Res Treat 1993;25(1):83-94: Shay JW; Wright WE; Werbin H
  Toward a molecular understanding of human breast cancer: a hypothesis.
  
• Br J Dermatol 1990 Apr;122 (1):Suppl 35 p115-9: Lehmann AR; Bridges BA
  Sunlight-induced cancer: some new aspects and implications of the xeroderma pigmentosum model.
  
• Mutat Res 1991 Sep-Oct;250(1-2):3-16: Ames BN; Gold LS
  Endogenous mutagens and the causes of aging and cancer.
  
• Mutat Res 1991 Mar-Nov;256(2-6):139-48: Rao KM; Cohen HJ
  Actin cytoskeletal network in aging and cancer.
  
• Int J Cancer 1990 Apr 15;45(4):731-6: Reeves WC; Griffith JW; Wood MA; Whitesell L
  Exacerbation of doxorubicin cardiotoxicity by digoxin administration in an experimental rabbit model.
  
• Exp Gerontol 1986;21(6):483-95: Macieira-Coelho A
  Cancer and aging.
  
• Adv Cancer Res 1983;40 (1):365-424: Anisimov VN
  Carcinogenesis and aging.
  
• J Am Acad Dermatol 1983 Oct;9(4):487-502: Epstein JH
  Photocarcinogenesis, skin cancer, and aging.
  
• J Exp Zool 1983 Nov;228(2):287-95: Jones PA; Taylor SM; Wilson V
  DNA modification, differentiation, and transformation.
  
• Int J Biochem 1981;13(6):659-72: Hocman G
  Biochemistry of ageing and cancer.
  
• Q Rev Biol 1978 Jun;53(2):115-41: Trosko JE; Chang CC
  Environmental carcinogenesis: an integrative model.
  
• Science 1979 May 11;204(4393):587-93: Ames BN
  Identifying environmental chemicals causing mutations and cancer.
  
• Fed Proc 1975 Jan;34(1):64-7: Daniel CW; Aidells BD; Medina D; Faulkin LJ Jr
  Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation.
  
• Rev Fr Gynecol Obstet 1991 Jun;86(6):448-50: Berbis P
  [Cutaneous senescence and carcinogenesis]
  
• Ann N Y Acad Sci 1991;621 (1):373-84: Anisimov VN
  Effects of factors prolonging life span on carcinogenesis.
  
• Mutat Res 1992 Jun;267(2):277-90: Simic MG
  Urinary biomarkers and the rate of DNA damage in carcinogenesis and anticarcinogenesis.
  
• Br J Dermatol 1990 Apr;122 (1):Suppl 35 p55-60: Rogers GS; Gilchrest BA
  The senile epidermis: environmental influences on skin ageing and cutaneous carcinogenesis.
  
• Usp Sovrem Biol 1981 Nov-Dec;92(3):455-72: Anisimov VN
  [Effect of geroprotectors on carcinogenesis]
  

Telomeres, Cellular Senescence, Apoptosis and Aging

Telomeres

• Nippon Rinsho 1993 Jul;51(7):1899-906: Ohmura H; Oshimura M
  [Telomere, cellular senescence and transformation]
  
• Mutat Res 1991 Mar-Nov;256(2-6):271-82: Harley CB
  Telomere loss: mitotic clock or genetic time bomb?
  
• Bioessays 1990 Aug;12(8):363-9: Greider CW
  Telomeres, telomerase and senescence.
  

Apoptosis/Programmed Cell Death

• J Cell Biochem 1994 Apr;54(4):432-9: Wang E; Lee MJ; Pandey S
  Control of fibroblast senescence and activation of programmed cell death.
  
• Ann N Y Acad Sci 1992 Dec 26;673 (1):70-82: Monti D; Grassilli E; Troiano L; Cossarizza A; Salvioli S; Barbieri D; Agnesini C; Bettuzzi S; Ingletti MC; Corti A; et al
  Senescence, immortalization, and apoptosis. An intriguing relationship.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):234-49: Lockshin RA; Zakeri ZF
  Physiology and protein synthesis in programmed cell death. Early synthesis and DNA degradation.
  
• Am J Clin Nutr 1992 Jun;55(6 Suppl):1208S-1214S: Monti D; Troiano L; Tropea F; Grassilli E; Cossarizza A; Barozzi D; Pelloni MC; Tamassia MG; Bellomo G; Franceschi C
  Apoptosis--programmed cell death: a role in the aging process?
  
• J Gerontol 1990 Sep;45(5):B135-40: Lockshin RA; Zakeri ZF
  Programmed cell death: new thoughts and relevance to aging.
  
• Seikagaku 1994 Apr;66(4):359-63: Fujita T
  [Gerontological significance of senescence marker protein-30 (SMP30)]
  
• Cell Struct Funct 1994 Feb;19(1):1-10: Wadhwa R; Kaul SC; Mitsui Y
  Cellular mortality to immortalization: mortalin.
  
• Physiol Rev 1993 Jul;73(3):617-38: Cristofalo VJ; Pignolo RJ
  Replicative senescence of human fibroblast-like cells in culture.
  
• J Am Geriatr Soc 1993 Nov;41(11):1255-8: Goletz TJ; Hensler PJ; Ning Y; Adami GR; Pereira-Smith OM
  Evidence for a genetic basis for the model system of cellular senescence.
  
• Med Hypotheses 1993 Oct;41(4):384-9: Chigira M; Watanabe H
  Is 'senescence' of diploid cells an ad hoc mechanism suppressing 'replicon' or not?
  
• Ann Med 1992 Oct;24(5):313-8: Koli K; Keski-Oja J
  Cellular senescence.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):503-17: Wang E
  Characterization of the absence of an unique DNA-binding protein in senescent but not in their young growing and nongrowing counterparts provides the means to mark the final stage of the cellular aging process.
  
• Exp Gerontol 1992 Jul-Aug;27(4):391-5: Norwood TH; Pendergrass WR; Saulewicz A; Hanaoka F
  A somatic genetic approach to the analysis of senescence in human diploid fibroblasts in vitro: from heterokaryons to molecules.
  
• Mech Ageing Dev 1992 Aug;65(1):85-107: Danner DB
  The proliferation theory of rejuvenation.
  
• Exp Gerontol 1992 Sep-Dec;27(5-6):519-22: Pereira-Smith OM; Ning Y
  Molecular genetic studies of cellular senescence.
  
• Acta Biochim Pol 1993;40(3):389-94: Sikora E
  Transcription factors in cellular senescence and death.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):187-94: Cristofalo VJ; Pignolo RJ; Rotenberg MO
  Molecular changes with in vitro cellular senescence.
  
• Exp Gerontol 1992 Jul-Aug;27(4):383-9: Wright WE; Shay JW
  The two-stage mechanism controlling cellular senescence and immortalization.
  
• Adv Exp Med Biol 1993;330 (1):45-53: Jazwinski SM; Chen JB; Sun J
  A single gene change can extend yeast life span: the role of Ras in cellular senescence.
  
• Toxicol Lett 1993 Apr;67(1-3):211-30: Newbold RF; Cuthbert AP; Themis M; Trott DA; Blair AL; Li W
  Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis.
  
• Exp Gerontol 1992 Jul-Aug;27(4):429-32: Cristofalo VJ; Pignolo RJ; Cianciarulo FL; Di Paolo BR; Rotenberg MO
  Changes in gene expression during senescence in culture.
  
• Mutat Res 1991 Mar-Nov;256(2-6):263-9: Spiering AL; Smith JR
  Negative growth effectors and cellular senescence.
  
• Rev Neurol (Paris) 1991;147(6-7):532-5: Byrne E; Dennett X; Trounce I
  Oxidative energy failure in post-mitotic cells: a major factor in senescence.
  
• Curr Opin Cell Biol 1991 Apr;3(2):230-4: McCormick A; Campisi J
  Cellular aging and senescence.
  
• Mutat Res 1991 Mar-Nov;256(2-6):303-10: Ning Y; Pereira-Smith OM
  Molecular genetic approaches to the study of cellular senescence.
  
• Mutat Res 1991 Mar-Nov;256(2-6):323-8: Kirkwood TB
  Genetic basis of limited cell proliferation.
  
• J Cell Biochem 1991 Feb;45(2):147-55: Peacocke M; Campisi J
  Cellular senescence: a reflection of normal growth control, differentiation, or aging?
  
• Exp Cell Res 1990 Nov;191(1):1-7: Linder S; Marshall H
  Immortalization of primary cells by DNA tumor viruses.
  
• Science 1990 Sep 7;249(4973):1129-33: Goldstein S
  Replicative senescence: the human fibroblast comes of age.
  
• J Gerontol 1990 Mar;45(2):B36-41: Holliday R
  The limited proliferation of cultured human diploid cells: regulation or senescence?
  
• J Gerontol 1990 Mar;45(2):B32-5: Smith JR
  DNA synthesis inhibitors in cellular senescence.
  
• Aging (Milano) 1989 Sep;1(1):3-15: Franceschi C
  Cell proliferation, cell death and aging.
  
• Genome 1989;31(1):386-9: Smith JR; Pereira-Smith OM
  Altered gene expression during cellular aging.
  
• Mech Ageing Dev 1984 Oct 15;27(2):257-62: Macieira-Coelho A
  Genome reorganization during cellular senescence.
  
• Mech Ageing Dev 1987 Mar;38(1):1-48: Stanulis-Praeger BM
  Cellular senescence revisited: a review.
  
• Cellule 1987;74 (1):317-73: Van Gansen P; Van Lerberghe N
  [Possibilities and limitations of fibroblast cultures in the study of animal aging]
  
• Clin Haematol 1985 Feb;14(1):223-57: Clark MR; Shohet SB
  Red cell senescence.
  
• Endeavour 1982;6(4):162-7: Knook DL
  Aging of cells: accident or programme?
  
• Mol Cell Biochem 1981 May 26;36(3):169-76: Reff M; Schneider EL
  Cell culture aging.
  
• Gerontology 1980;26(3):138-54: Whatley SA; Hill BT
  In vitro 'ageing' and nuclear template function.
  
• Int Rev Cytol Suppl 1979;(10):67-76: Levine EM; Mueller SN
  Cultured vascular endothelial cells as a model system for the study of cellular senescence.
  
• Int Rev Cytol 1978;54 (1):161-91: Rosen R
  Cells and senescence.
  
• : Day RS 3d
  Inducible error-prone repair and cellular senescence. pp. 217-23.
  
• MISSING SOURCE: Lett JT
  Cellular senescence and the capacity for rejoining DNA strand breaks. pp. 89-98.
  
• Am J Pathol 1977 Nov;89(2):484-511: Martin GM
  Cellular aging--clonal senescence. A review (Part I).
  
• Mech Ageing Dev 1975 Sep-Dec;4(5-6):339-48: Good PI
  Aging in mammalian cell population: a review.
  
• Fed Proc 1975 Jan;34(1):51-5: Holliday R
  Growth and death of diploid and transformed human fibroblasts.
  

Protein Damage and Aging

• Mutat Res 1992 Sep;275(3-6):387-93: Dean RT; Gebicki J; Gieseg S; Grant AJ; Simpson JA
  Hypothesis: a damaging role in aging for reactive protein oxidation products?
  
• Am J Hematol 1993 Mar;42(3):241-7: Kosower NS
  Altered properties of erythrocytes in the aged.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):63-70: Lee AT; Cerami A
  Role of glycation in aging.
  
• Science 1992 Aug 28;257(5074):1220-4: Stadtman ER
  Protein oxidation and aging.
  
• Diabetes 1992 Oct;41 (1):Suppl 2 p36-41: Monnier VM; Sell DR; Nagaraj RH; Miyata S; Grandhee S; Odetti P; Ibrahim SA
  Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia.
  
• Gerontology 1991;37(1-3):152-65: Monnier VM; Sell DR; Nagaraj RH; Miyata S
  Mechanisms of protection against damage mediated by the Maillard reaction in aging.
  
• Mutat Res 1991 Mar-Nov;256(2-6):255-62: Rosenberger RF
  Senescence and the accumulation of abnormal proteins.
  
• Mutat Res 1991 Mar-Nov;256(2-6):243-54: Wadhwa R; Kaul SC; Ikawa Y; Sugimoto Y
  Protein markers for cellular mortality and immortality.
  
• Hemoglobin 1990;14(4):353-88: Ohba Y
  Unstable hemoglobins.
  
• J Am Geriatr Soc 1986 Apr;34(4):282-94: Tollefsbol TO; Cohen HJ
  Role of protein molecular and metabolic aberrations in aging, in the physiologic decline of the aged, and in age-associated diseases.
  
• Biol Rev Camb Philos Soc 1983 Aug;58(3):343-422: Makrides SC
  Protein synthesis and degradation during aging and senescence.
  
• Mech Ageing Dev 1979 Feb;9(3-4):189-96: Gershon D
  Current status of age altered enzymes: alternative mechanisms.
  
• Physiol Rev 1975 Jul;55(3):418-87: Gallop PM; Paz MA
  Posttranslational protein modifications, with special attention to collagen and elastin.
  

Exercise and Aging

• Geriatrics 1993 May;48(5):61-4: Shephard RJ
  Exercise and aging: extending independence in older adults.
  
• Arch Intern Med 1987 Feb;147(2):353-6: Larson EB; Bruce RA
  Health benefits of exercise in an aging society.
  
• Heart Lung 1984 Sep;13(5):519-24: Holm K; Kirchhoff KT
  Perspectives on exercise and aging.
  
• Exerc Sport Sci Rev 1978;6 (1):1-57: Shephard RJ; Sidney KH
  Exercise and aging.
  
• Med Sci Sports Exerc 1994 Feb;26(2):172-81: Nieman DC; Henson DA
  Role of endurance exercise in immune senescence.
  

Sex Specific Longevity Differences

• Mech Ageing Dev 1993 Dec 15;72(2):89-95: Magnani M; Accorsi A
  The female longevity phenomenon. Hypotheses on some molecular and cell biology aspects.
  
• Gerontology 1983;29(5):336-52: Lints FA; Bourgois M; Delalieux A; Stoll J; Lints CV
  Does the female life span exceed that of the male? A study in Drosophila melanogaster.
  

Accelerated Aging Diseases

• Annu Rev Gerontol Geriatr 1990;10 (1):23-42: Brown WT
  Genetic diseases of premature aging as models of senescence.
  

• Werners Syndrome

  • Bioessays 1993 Jun;15(6):421-6: Thweatt R; Goldstein S
    Werner syndrome and biological ageing: a molecular genetic hypothesis.
    
  • Hum Genet 1982;62(1):1-5: Salk D
    Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations.
    

Genes Involved in Aging

• Ann N Y Acad Sci 1992 Nov 21;663 (1):139-53: Fornace AJ Jr; Jackman J; Hollander MC; Hoffman-Liebermann B; Liebermann DA
  Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest.
  
• Exp Clin Immunogenet 1992;9(4):230-40: Burkle A; Grube K; Kupper JH
  Poly(ADP-ribosyl)ation: its role in inducible DNA amplification, and its correlation with the longevity of mammalian species.
  
• New Biol 1991 Sep;3(9):825-33: Holbrook NJ; Fornace AJ Jr
  Response to adversity: molecular control of gene activation following genotoxic stress.
  

Organ/System Specific Aging

Brain Aging

• Life Sci 1994;54(17):1205-14: Castorina M; Ferraris L
  Acetyl-L-carnitine affects aged brain receptorial system in rodents.
  
• J Neural Transm Suppl 1993;40 (1):37-45: Glover V; Clow A; Sandler M
  Effects of dopaminergic drugs on superoxide dismutase: implications for senescence.
  
• J Neural Transm Suppl 1993;40 (1):57-67: Youdim MB; Riederer P
  The role of iron in senescence of dopaminergic neurons in Parkinson's disease.
  
• J Neural Transm Gen Sect 1993;91(2-3):135-59: Palmer AM; De Kosky ST
  Monoamine neurons in aging and Alzheimer's disease.
  
• Med Lab Sci 1992 Dec;49(4):271-82: Mera SL
  Senescence and pathology in ageing.
  
• Prog Brain Res 1992;93 (1):237-47; discussion 247-8: Goudsmit E; Neijmeijer-Leloux A; Swaab DF
  The human hypothalamo-neurohypophyseal system in relation to development, aging and Alzheimer's disease.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):376-83: Algeri S
  Potential strategies against age-related brain deterioration. Dietary and pharmacological approaches.
  
• Ann N Y Acad Sci 1992 Nov 21;663 (1):279-93: Peterson C
  Changes in calcium's role as a messenger during aging in neuronal and nonneuronal cells.
  
• Int J Neurosci 1990 Feb;50(3-4):169-74: Mazzarello P; Focher F; Verri A; Spadari S
  Misincorporation of uracil into DNA as possible contributor to neuronal aging and abiotrophy.
  
• Nebr Symp Motiv 1991;39 (1):1-37: Birren JE; Fisher LM
  Aging and slowing of behavior: consequences for cognition and survival.
  
• Neurobiol Aging 1991 Jul-Aug;12(4):317-24: Swaab DF
  Brain aging and Alzheimer's disease, "wear and tear" versus "use it or lose it" [see comments]
  
• Neurobiol Aging 1991 Jul-Aug;12(4):328-30; discussion 352-5: Davies I
  Comments on review by Swaab--brain aging and Alzheimer's disease. "Wear and tear" versus "use it or lose it" [comment]
  
• Mutat Res 1991 Mar-Nov;256(2-6):221-31: Carmeliet G; David G; Cassiman JJ
  Cellular ageing of Alzheimer's disease and Down syndrome cells in culture.
  
• Life Sci 1991;48(5):373-85: Magnoni MS; Govoni S; Battaini F; Trabucchi M
  The aging brain: protein phosphorylation as a target of changes in neuronal function.
  
• Tohoku J Exp Med 1990 Aug;161 (1):Suppl p49-60: Nakamura S
  Senile dementia and presenile dementia.
  
• Int J Clin Pharmacol Res 1990;10(1-2):49-51: Fariello RG
  Peroxidative stress and cerebral aging.
  
• Compr Gerontol [A] 1987 Feb;1(1):4-15: Sarter M
  Animal models of brain ageing and dementia.
  
• Dermatol Clin 1986 Jul;4(3):501-7: Kligman AM; Graham JA
  The psychology of appearance in the elderly.
  
• J Neuroimmunol 1985 Nov;10(1):41-58: Walker RF; Codd EE
  Neuroimmunomodulatory interactions of norepinephrine and serotonin.
  
• J Am Geriatr Soc 1985 Mar;33(3):184-8: Heinsimer JA; Lefkowitz RJ
  The impact of aging on adrenergic receptor function: clinical and biochemical aspects.
  
• Mech Ageing Dev 1985 May 13;30(2):109-22: Knoll J
  The facilitation of dopaminergic activity in the aged brain by (-)deprenyl. A proposal for a strategy to improve the quality of life in senescence.
  
• Presse Med 1983 Mar 24;12(13):809-14: Ollat H; Sebban C
  [Histological lesions and changes in neurotransmitter systems in the aged brain. Discussion of their pathogenic role]
  
• J Am Geriatr Soc 1983 Mar;31(3):137-43: Avorn J
  Biomedical and social determinants of cognitive impairment in the elderly.
  
• Rev Electroencephalogr Neurophysiol Clin 1981 Jul-Sep;10(3):197-206: Baumann N; Hauw JJ
  [The biochemistry of cerebral aging in man and in experimental models (author's transl)]
  
• Fortschr Neurol Psychiatr Grenzgeb 1976 Nov;44(11):617-33: Jacob H
  [The neurobiology of the successive stages of life (author's transl)]
  
• J Am Geriatr Soc 1976 Jan;24(1):4-11: Samorajski T
  How the human brain responds to aging.
  

Skin Aging

• Z Gerontol 1994 May-Jun;27(3):182-5: Vogel HG
  [Age-dependent changes in skin biomechanics, measurements in vitro and in vivo]
  
• Arch Dermatol 1994 Jan;130(1):87-95: West MD
  The cellular and molecular biology of skin aging.
  
• Experientia 1993 Sep 15;49(9):747-53: Ambach W; Blumthaler M
  Biological effectiveness of solar UV radiation in humans.
  
• Acta Med Port 1990 Sep-Oct;3(5):311-8: Rodrigo FG; Mayer-da-Silva AJ; Freitas JP
  [Skin aging. Physiopathology and clinical perspective (see comments)]
  
• Br J Dermatol 1990 Apr;122 (1):Suppl 35 p1-3: Leyden JJ
  Clinical features of ageing skin.
  
• J Dermatol Surg Oncol 1990 Oct;16(10):915-22: Yaar M; Gilchrest BA
  Cellular and molecular mechanisms of cutaneous aging.
  
• Nippon Hifuka Gakkai Zasshi 1990 Nov;100(13):1326-7: Takebe H
  [Light and skin]
  
• Br J Dermatol 1990 Apr;122 (1):Suppl 35 p37-41: Raab WP
  The skin surface and stratum corneum.
  
• J Int Med Res 1990;18 (1):Suppl 3 p2C-7C: Raab WP
  Photodamaged skin: a medical or a cosmetic concern?
  
• Br J Dermatol 1990 Apr;122 (1):Suppl 35 p43-8: Stuttgen G; Ott A
  Senescence in the skin.
  
• Br J Dermatol 1990 Apr;122 (1):Suppl 35 p111-4: Young AR
  Senescence and sunscreens [see comments]
  
• Z Hautkr 1989 Nov 15;64(11):1019-20, 1025-6: Roeser BE; Budde J; Tronnier H
  [Therapy of aging skin]
  
• Dermatol Clin 1986 Jul;4(3):359-69: Praeger B
  In-vitro studies of aging.
  

Liver Aging

• J Electron Microsc Tech 1990 Feb;14(2):106-25: Schmucker DL
  Hepatocyte fine structure during maturation and senescence.
  
• Gastroenterol Clin North Am 1990 Jun;19(2):459-72: Van Dam J; Zeldis JB
  Hepatic diseases in the elderly.
  

Kidney Aging

• Clin Geriatr Med 1985 Feb;1(1):207-22: Kaysen GA; Myers BD
  The aging kidney.
  
• Clin Geriatr Med 1994 Feb;10(1):197-211: Sica DA
  Renal disease, electrolyte abnormalities, and acid-base imbalance in the elderly.
  
• Environ Health Perspect 1990 Mar;84 (1):137-40: Liang CT; Hanai H; Ishida M; Cheng L; Sacktor B
  Regulation of renal sodium calcium exchange by PTH: alteration with age.
  
• Ann Cardiol Angeiol (Paris) 1991 May;40(5):309-15: Meyrier A
  [Renal senescence]
  

Heart and Vasculature Aging

• Presse Med 1992 Jul 22;21(26):1216-21: Swine C
  [Aging of heart function in man]
  
• Klin Med (Mosk) 1993;71(5):51-4: Bulychev VV
  [Longevity, atherosclerosis and cellular immunity]
  
• Cardioscience 1992 Jun;3(2):67-78: Muscari C; Caldarera I; Rapezzi C; Branzi A; Caldarera CM
  Biochemical correlates with myocardial aging.
  
• Prog Cardiovasc Nurs 1990 Oct-Dec;5(4):118-25: Holm K; Penckofer S
  Coronary heart disease: requisite knowledge for developing prevention strategies for the aging adult.
  
• Scanning Microsc 1991 Dec;5(4):1065-73; discussion 1073-4: Anversa P; Capasso JM
  Cellular basis of aging in the mammalian heart.
  
• Prog Cardiovasc Nurs 1990 Oct-Dec;5(4):118-25: Holm K; Penckofer S
  Coronary heart disease: requisite knowledge for developing prevention strategies for the aging adult.
  
• Presse Med 1992 Jul 22;21(26):1184-7: Camilleri JP
  [Structural approach of vascular aging]
  
• Adv Exp Med Biol 1975;61 (1):163-93: Martin G; Ogburn C; Sprague C
  Senescence and vascular disease.
  

Reproductive System

• Ann N Y Acad Sci 1991;622 (1):6-27: Ferenczy A; Bergeron C
  Histology of the human endometrium: from birth to senescence.
  
• Reprod Toxicol 1987-88;1(3):223-8: May PC; Finch CE
  Aging and responses to toxins in female reproductive functions.
  
• Birth Defects 1978;14(1):335-54: Finch CE
  Genotypic influences on female reproductive senescence in rodents.
  
• MISSING SOURCE: Hafez ES
  Reproductive senescence. pp. 1-19.
  

Miscellaneous System Age Changes

• Orthop Clin North Am 1992 Jul;23(3):381-94: Heller JG
  The syndromes of degenerative cervical disease.
  
• Clin Geriatr Med 1990 Feb;6(1):197-203: Gupta K
  Sexual dysfunction in elderly women.
  
• Clin Orthop 1992 Jan;(274):194-201: Poss R
  Natural factors that affect the shape and strength of the aging human femur.
  
• Oftalmol Zh 1980;35(7):387-91: Kashintseva LT
  [Aging processes and the eye]
  
• Prog Clin Biol Res 1978;28 (1):39-64: George JN
  Platelet behavior and aging in the circulation.
  
• Oral Surg Oral Med Oral Pathol 1991 Dec;72(6):721-45: Morse DR
  Age-related changes of the dental pulp complex and their relationship to systemic aging.
  
• Rev Fr Endod 1987 Mar;6(1):69-80: Ricci C
  [Pulpodentinal aging: review of the literature and diagnostic conclusions]
  
• Adv Surg 1991;24 (1):293-331: Koruda MJ; Sheldon GF
  Surgery in the aged.
  

Health Care

• N Engl J Med 1985 Mar 28;312(13):827-35: Rowe JW
  Health care of the elderly.
  

Biomarkers, Animal Models and Aging Study Design

• Lab Anim 1994 Apr;28(2):148-54: Roe FJ
  Historical histopathological control data for laboratory rodents: valuable treasure or worthless trash?
  
• Anthropol Anz 1993 Sep;51(3):233-49: Otremski I; Katz M; Livshits G; Cohen Z
  Biology of aging in an Israeli population. 1. Review of literature and morphological variation analysis.
  
• Comp Biochem Physiol A 1993 Jul;105(3):389-96: Le Bourg E; Lints FA; Fresquet N; Bullens P
  Hypergravity, aging and longevity in Drosophila melanogaster.
  
• Ann N Y Acad Sci 1992 Dec 26;673 (1):23-8: Marigliano V; Bauco C; Campana F; Cacciafesta M; Bagaglini E; Fritz C; Ettorre E
  Normal values in extreme old age.
  
• Biomed Environ Sci 1991 Jun;4(1-2):182-91: Duffy PH; Feuers RJ
  Biomarkers of aging: changes in circadian rhythms related to the modulation of metabolic output.
  
• Int J Neurosci 1991 Aug;59(4):259-62: Sandyk R; Anninos PA; Tsagas N
  Age-related disruption of circadian rhythms: possible relationship to memory impairment and implications for therapy with magnetic fields.
  
• J Am Geriatr Soc 1991 Jan;39(1):74-91: Brock MA
  Chronobiology and aging.
  
• Biomed Environ Sci 1991 Jun;4(1-2):130-3: Turturro A; Hart RW
  Biomarkers of aging: an overview.
  
• Neurobiol Aging 1991 Nov-Dec;12(6):659-62: Deerberg F
  Age-associated versus husbandry-related pathology of aging rats.
  
• Neurobiol Aging 1991 Nov-Dec;12(6):695-7: Rogers J
  Efficient experimental design in aging studies.
  
• Neurobiol Aging 1991 Nov-Dec;12(6):639-43: Masoro EJ
  Use of rodents as models for the study of "normal aging": conceptual and practical issues.
  
• Med Sci Sports Exerc 1987 Apr;19(2):174-8: Sharkey BJ
  Functional vs chronologic age.
  
• Exp Aging Res 1986 Spring;12(1):3-21: Cheal ML
  The gerbil: a unique model for research on aging.
  
• Birth Defects 1978;14(1):71-96: Sacher GA; Hart RW
  Longevity, aging and comparative cellular and molecular biology of the house mouse, Mus musculus, and the white-footed mouse, Peromyscus leucopus.
  
• Birth Defects 1978;14(1):41-53: Myers DD
  Review of disease patterns and life span in aging mice: genetic and environmental interactions.
  

Unclassified References

• BJR Suppl 1992;24 (1):65-9: Deeley JO; Moore JL
  Single-cell microgel electrophoresis: an in vitro assay of radiosensitivity.
  
• Med Hypotheses 1993 Oct;41(4):316-24: McCarty MF
  Homologous physiological effects of phenformin and chromium picolinate.
  
• Arch Environ Health 1990 Mar-Apr;45(2):80-7: Steinberg JJ; Gleeson JL; Gil D
  The pathobiology of ozone-induced damage.
  
• Bioessays 1991 Nov;13(11):601-6: Rattan SI; Derventzi A
  Altered cellular responsiveness during ageing.
  
• Microbiol Rev 1991 Dec;55(4):561-85: Farr SB; Kogoma T
  Oxidative stress responses in Escherichia coli and Salmonella typhimurium.
  
• Med Sci Sports Exerc 1991 May;23(5):586-93: Pitetti KH; Campbell KD
  Mentally retarded individuals--a population at risk?
  
• J Nutr 1990 Nov;120 (1):Suppl 11 p1508-11: Bailey LB
  Folate status assessment.
  
• Eye 1987;1 ( Pt 2):304-10: Mainster MA
  Light and macular degeneration: a biophysical and clinical perspective.
  
• Am J Med 1986 May;80(5):906-10: Messerli FH
  Osler's maneuver, pseudohypertension, and true hypertension in the elderly.
  
• Chest 1987 Jun;91(6 Suppl):119S-126S: Buist AS; Vollmer WM
  Prospective investigations in asthma. What have we learned from longitudinal studies about lung growth and senescence in asthma?
  
• Crit Rev Clin Lab Sci 1986;23(3):201-17: Mayer K; Freeman JE
  Techniques for measuring red cell, platelet, and WBC survival.
  
• Usp Sovrem Biol 1982 Nov-Dec;94(3):421-32: Nikitin VN
  [Leading problems of modern age-related physiology, biochemistry and biophysics and the research of the Nagornyi school]
  
• Crit Rev Biomed Eng 1982;8(3):223-52: Spelman FA
  The cochlear prosthesis: a review of the design and evaluation of electrode implants for the profoundly deaf.
  
• Mech Ageing Dev 1979 Feb;9(3-4):303-11: Schneider EL; Kram D; Nakanishi Y; Monticone RE; Tice RR; Gilman BA; Nieder ML
  The effect of aging on sister chromatid exchange.
  
• Adv Exp Med Biol 1978;97 (1):187-206: Clemens JA; Fuller RW
  Chemical manipulation of some aspects of aging.